Importance of Chloromethyl Isopropyl Carbonate as a pharma intermediate

Key Importance of CMIC

Purity of chemicals is the most important thing and all reputed manufacturers take responsibility toward the purity of chemicals they manufacture. The quality of component chemicals ensures the success of the outcome for which they are to be used. This is especially true about CMIC which is used to manufacture Tenofovir, a medicine that can combat HIV AIDS together with other medicines.

CMIC which stands for Chloromethyl Isopropyl Carbonate has huge demand in the market. As a primary component in the development of Tenofovir, it is indeed one of the significant chemicals that are demanded in the purest form. Known as an antiretroviral medicine that can also fight chronic disease like Hepatitis B, Tenofovir finds its place in the essential drugs list of WHO. Tenofovir is forms a part of the treatment prescribed and is given in combination with other medicines.

This pharma intermediate is developed with the help of best equipment and by the use of latest technology. Throughout its production high standard is maintained so that the final product is of best quality. This is essential because only then its job as a pharmaceutical intermediate will be completed. Its purity, composition and shelf life is extremely important to ensure a longer shelf life. For those companies who are looking for the supply of this intermediate for large scale use, these factors are of utmost importance.

Preparation of Tenofovir Disoproxil

Tenofovir is carefully added to cyclohexane in a ratio of 1:8 at a temperature range of 25 to 35 degree Celsius. The process is conducted in the presence of nitrogen. The temperature of the reaction rises to reflux. The moisture content is also separated with the help of azeotropic distillation. When the temperature of the reaction increases to 54 to 58 degree centigrade, Chloromethyl Isopropyl Carbonate is added. Thereafter, step by step process is followed in order to get the desired outcome.

Importance of CMIC

It has chemical formula C5H9ClO3 and is a pharma intermediate of great significance. It has several applications apart from being used in the development of anti HIV AIDS medicine. It should be stored and packaged carefully so that it is not leaked in the atmosphere.

CMIC holds an important place among the pharma intermediates. It has huge market demand and therefore it is manufactured by some of the best known companies with quality infrastructure and the right kind of system and processes. In India there are some companies which can offer this chemical with purity of 99.9%. The available expertise of these companies let them offer quality products used in developing various Pharmaceutical Chemicals products such as HMDSO, HMDS, and TMCS etc. With their quality driven approach they are able to satisfy not only the domestic clients, but, also the international buyers.

Advance strategies - Bulk Drug Intermediates for Pharma Industries

Specialty chemicals global sector:

Specialty chemicals and pharmaceutical chemicals, over the decades have gained a lot of popularity in India. Specialty chemicals industry is a very wide and complex segment. It includes variety of products like agrichemicals, elastomers, adhesives, lubricants, oil field chemicals, etc. Worldwide, the specialty chemicals industry has grown into an array of SME’s with their own niche products. The specialty chemicals market has played a significant part in the global chemical sector. The global demand for specialty chemicals is expected to grow at a CAGR of 5.42% from 2015 to 2020.

Various Applications:

Specialty chemicals in Gujarat provide unique materials with unique properties that produce high value custom end products. They have various applications. Specialty chemicals are the chemicals which are used to boast the performance of other chemicals that can be apply in many potential experiments in the chemical industry. One of the most important applications of specialty chemicals is to speed up the manufacturing process of various chemical experiments. They help to get deliverables with less experimental costs and efforts. Some of the specialty chemicals act like value-adders that add value to other chemicals to perform more in less time.

Specialty chemicals Market Range:

North America, Western European, and Japanese firms were always amongst the market leaders in specialty chemicals industry. However, over the last few decades the Asia-Pacific region, especially India and China have globally stated their dominance in the specialty chemicals industry. In India, the speciality chemicals in Gujarat have gained a lot of dominance in this sector and have been providing their end products.

Types of Bulk Drug Intermediates:

Pharmaceutical Chemicals form the most important branch of specialty chemicals. The Pharmaceutical industry in India is the world's third-largest in terms of volume and 10th largest in value terms. . India's drugs and pharmaceuticals industry is expected to grow at a compound annual growth rate (CAGR) of 14 per cent to reach a turnover of $ 47.06 billion by 2018. Indian pharmaceutical industry is gaining rapid popularity owing to the rise in the bulk drug intermediates manufacturers. In India, Gujarat is considered to be the rising hub in the production of pharmaceutical intermediates and bulk drug intermediates. Last ten decades have seen an immense growth in SME niche pharmaceutical intermediates producing companies. Various pharma intermediates like Hexamethyl Disiloxane (HMDSO), Trimethyl Chlorosilane (TMCS), Hexamethyl Disilazane (HMDS / HMDZ) Chloromethyl Isopropyl Carbonate (CMIC) are produced and exported worldwide by these small scale manufacturers in Gujarat.

Applications of Pharmaceutical Intermediates like as lubricants, as adhesion promoter for photoresists, in alkylation agents, in creation of sedatives, medicines, in manufacturing of anhydrous solutions of HCL in alcohols, deactivator for chromatographic support materials, silylating agent in pharmaceuticals, etc.

With all the end products possessing these properties have been exported on a large scale from Gujarat, it is recognized as the upcoming hub in the field of specialty chemicals and bulk pharma intermediates.

Manufacture of pharmaceutical intermediates in Gujarat

Chemcon Speciality Chemicals Pvt. Ltd. is a pharmaceutical chemicals specialty leading in the manufacturing of pharma intermediates like Hexamethyl Disiloxane (HMDSO) CAS NO. : 107-46-0, Trimethyl Chlorosilane (TMCS) CAS NO. : 75-77-4 and Chloromethyl Isopropyl Carbonate (CMIC ) CAS No. 35180-01-9. Chemcon is the largest manufacturer in India since a decade for Hexamethyldisilazane. The processes for the manufacture of all these products have been developed and engineered in-house by the team of dedicated and expert in-house professionals with in-depth knowledge in the field. We enjoy the highest reputation among Indian as well as Multi-National Companies for being a leading HMDSO, CMIC, and Trimethyl Chlorosilane in India

Three of our most significant products are:

Hexamethyl Disiloxane (HMDSO) CAS NO. : 107-46-0

We specialize in the Manufacture of HMDSO in Gujarat which has many applications like:

•    HMDSO is a pharma intermediate which is very popular in the pharmaceutical industry due to its various applications.

•    It is an organosilicon compound, volatile in nature. It is also used as a reagent and a solvent in various organic syntheses.

•    It is also used as in spectroscopy to standardize the chemical shift.

•    The most important use of HMDSO is in crystallizing of lipophilic compunds.

•    Also used in preparation of liquid bandages.

•    It is manufactured through hydrolysis of trimethlsilyl chloride.

Trimethyl Chlorosilane (TMCS ) CAS NO. : 75-77-4

As India’s leading TMCS Manufacturer in Vadodara, we produce TMCS that has very useful applications in the field of pharmacy like:

•    Trimethyl Chlorosilane is used in the manufacture of all types of silicon compounds.

•    It is widely used in the manufacture of drugs and medicines.

•    It reacts with alcohol to produce anhydrous solutions of hydrogen chloride (HCL) in alcohols that can be used for the synthesis of esters.

•    It has also been used for silylation and as a protection group in the process of various organic syntheses.

•    But the most important application of TMCS is in the preparation of HMDSO.

•    Hydrolysis of TMCS in preparation of HMDSO:

TMCS is reactive toward nucleophiles, resulting in the replacement of the chloride. In a characteristic reaction of TMCS, the nucleophile is water, resulting in hydrolysis to give the Hexamethyl Disiloxane

2(CH3)3SiCl+H2O→ (CH3)3SiO(CH3)3Si+2HCl

Chloromethyl Isopropyl Carbonate (CMIC) CAS No. 35180-01-9

Chemcon prides in its manufacture of CMIC because of its outstanding application to prepare tenofovir. Tenofovir is regarded as a revolutionary drug for curing and preventing AIDS/HIV. Tenofovir disoproxil hemifumarate salt is basically prepared using dealkylating (R)-9-[2-(Diethyl phosphonomethoxy) propyl] adenine. To get a crystallized tenofovir in its stable form, Chloromethyl Isopropyl Carbonate is Used, where it is used to condense tenofovir during the latter’s initial phase of manufacture.

These are some of the importance of pharma intermediates which have revolutionalized the field of specialty chemicals worldwide and Chemcon is one of the world’s leading manufacturers of specialty chemicals and pharma intermediates.