Importance of Chloromethyl Isopropyl Carbonate as a pharma intermediate

Key Importance of CMIC

Purity of chemicals is the most important thing and all reputed manufacturers take responsibility toward the purity of chemicals they manufacture. The quality of component chemicals ensures the success of the outcome for which they are to be used. This is especially true about CMIC which is used to manufacture Tenofovir, a medicine that can combat HIV AIDS together with other medicines.

CMIC which stands for Chloromethyl Isopropyl Carbonate has huge demand in the market. As a primary component in the development of Tenofovir, it is indeed one of the significant chemicals that are demanded in the purest form. Known as an antiretroviral medicine that can also fight chronic disease like Hepatitis B, Tenofovir finds its place in the essential drugs list of WHO. Tenofovir is forms a part of the treatment prescribed and is given in combination with other medicines.

This pharma intermediate is developed with the help of best equipment and by the use of latest technology. Throughout its production high standard is maintained so that the final product is of best quality. This is essential because only then its job as a pharmaceutical intermediate will be completed. Its purity, composition and shelf life is extremely important to ensure a longer shelf life. For those companies who are looking for the supply of this intermediate for large scale use, these factors are of utmost importance.

Preparation of Tenofovir Disoproxil

Tenofovir is carefully added to cyclohexane in a ratio of 1:8 at a temperature range of 25 to 35 degree Celsius. The process is conducted in the presence of nitrogen. The temperature of the reaction rises to reflux. The moisture content is also separated with the help of azeotropic distillation. When the temperature of the reaction increases to 54 to 58 degree centigrade, Chloromethyl Isopropyl Carbonate is added. Thereafter, step by step process is followed in order to get the desired outcome.

Importance of CMIC

It has chemical formula C5H9ClO3 and is a pharma intermediate of great significance. It has several applications apart from being used in the development of anti HIV AIDS medicine. It should be stored and packaged carefully so that it is not leaked in the atmosphere.

CMIC holds an important place among the pharma intermediates. It has huge market demand and therefore it is manufactured by some of the best known companies with quality infrastructure and the right kind of system and processes. In India there are some companies which can offer this chemical with purity of 99.9%. The available expertise of these companies let them offer quality products used in developing various Pharmaceutical Chemicals products such as HMDSO, HMDS, and TMCS etc. With their quality driven approach they are able to satisfy not only the domestic clients, but, also the international buyers.

Advance strategies - Bulk Drug Intermediates for Pharma Industries

Specialty chemicals global sector:

Specialty chemicals and pharmaceutical chemicals, over the decades have gained a lot of popularity in India. Specialty chemicals industry is a very wide and complex segment. It includes variety of products like agrichemicals, elastomers, adhesives, lubricants, oil field chemicals, etc. Worldwide, the specialty chemicals industry has grown into an array of SME’s with their own niche products. The specialty chemicals market has played a significant part in the global chemical sector. The global demand for specialty chemicals is expected to grow at a CAGR of 5.42% from 2015 to 2020.

Various Applications:

Specialty chemicals in Gujarat provide unique materials with unique properties that produce high value custom end products. They have various applications. Specialty chemicals are the chemicals which are used to boast the performance of other chemicals that can be apply in many potential experiments in the chemical industry. One of the most important applications of specialty chemicals is to speed up the manufacturing process of various chemical experiments. They help to get deliverables with less experimental costs and efforts. Some of the specialty chemicals act like value-adders that add value to other chemicals to perform more in less time.

Specialty chemicals Market Range:

North America, Western European, and Japanese firms were always amongst the market leaders in specialty chemicals industry. However, over the last few decades the Asia-Pacific region, especially India and China have globally stated their dominance in the specialty chemicals industry. In India, the speciality chemicals in Gujarat have gained a lot of dominance in this sector and have been providing their end products.

Types of Bulk Drug Intermediates:

Pharmaceutical Chemicals form the most important branch of specialty chemicals. The Pharmaceutical industry in India is the world's third-largest in terms of volume and 10th largest in value terms. . India's drugs and pharmaceuticals industry is expected to grow at a compound annual growth rate (CAGR) of 14 per cent to reach a turnover of $ 47.06 billion by 2018. Indian pharmaceutical industry is gaining rapid popularity owing to the rise in the bulk drug intermediates manufacturers. In India, Gujarat is considered to be the rising hub in the production of pharmaceutical intermediates and bulk drug intermediates. Last ten decades have seen an immense growth in SME niche pharmaceutical intermediates producing companies. Various pharma intermediates like Hexamethyl Disiloxane (HMDSO), Trimethyl Chlorosilane (TMCS), Hexamethyl Disilazane (HMDS / HMDZ) Chloromethyl Isopropyl Carbonate (CMIC) are produced and exported worldwide by these small scale manufacturers in Gujarat.

Applications of Pharmaceutical Intermediates like as lubricants, as adhesion promoter for photoresists, in alkylation agents, in creation of sedatives, medicines, in manufacturing of anhydrous solutions of HCL in alcohols, deactivator for chromatographic support materials, silylating agent in pharmaceuticals, etc.

With all the end products possessing these properties have been exported on a large scale from Gujarat, it is recognized as the upcoming hub in the field of specialty chemicals and bulk pharma intermediates.

Hexamethyl Disilazane as an Alternative to Critical Point Drying

Critical point drying (CPD) is an established method of dehydrating biological tissue prior to examination in the Scanning Electron Microscope (SEM). This technique was first introduced to preserve three-dimensional structure of biological specimens for transmission electron microscopy, later it was used for obtaining dry specimens for SEM examination. Although CPD is a well-established method for drying specimens, there has been compelling evidence that it can damage soft specimens in two different ways: Structural integrity and Chemical Integrity. Over the years, use of the pharmaintermediate, Hexamethyl Disilazane (HMDS) in critical point drying is an established method of dehydrating biological tissue prior to examination in the SEM. Moreover, use HMDS in the imaging of cells on coal instead of CPD have led to negating the need for expensive equipment.

Studies on the applications of Hexamethyl Disilazane (HMDS) over Critical Point Drying (CPD):

• CPD and HMDS sample preparation techniques were used for testing the effects of both on the cervical cells on field emission scanning electron microscopy and energy dispersive X-ray. The results indicated that SEM imaging, elemental composition, and processing time for sample preparation with the HMDS technique were better than CPD technique for cervical cell preparation technique because in terms of weight percentages of carbon and oxygen element compositions in HMDS technique were higher than the CPD technique.

• CPD and HMDS samples used for preserving biological structures, revealed that samples prepared using CPD had tissue damage in the form of cracking. In addition there was excess amount of debris around the crack openings. Another potential result that placed HMDS as a superior drying agent is the time constraints that can be effective parameters while preparing more specimens; use of the Pharma Intermediate may be preferred over the traditional technique as it allows multiple samples to be dried simultaneously.

Preventing the gas/liquid interface is the main goal of critical point drying (as well as the alternative process of HMDS). Whenever a liquid evaporates into the gaseous phase, large surface tension phenomena occur. These surface tensions can harm fine surface details on the surface of the sample. CPD usually takes up to 3 hours to perform. Using Hexamethyldisilazane instead of CPD is quicker and can yield acceptable results on some samples. When the sample is dehydrated to 100% ethanol, a fifty/fifty mix of ethanol/HMDS can be placed on the sample followed by 2 or 3 exchanges of HMDS. After these exchanges, sample is in a fume hood where HMDS evaporates off. The vapor pressure of HMDS is such that surface damage is minimal.

The pharmaintermediate, Hexamethyl Disilazane is extensively used to replace the critical drying technique in sample preparation of tardigrades for SEM imaging because conventional procedures required CPD apparatus or machines to achieve the suitable temperature/pressure combination to completely dehydrate specimens, but with HMDS, the specimens can be dehydrated by simply bathing them in HMDS, ethanol solution, eliminating the use of any special equipment. All in all, the use of HMDS in SEM instead of CPD is preferred as it is safer, cheaper and more practical.