Friday, 25 March 2016

Manufacture of pharmaceutical intermediates in Gujarat

Chemcon Speciality Chemicals Pvt. Ltd. is a pharmaceutical chemicals specialty leading in the manufacturing of pharma intermediates like Hexamethyl Disiloxane (HMDSO) CAS NO. : 107-46-0, Trimethyl Chlorosilane (TMCS) CAS NO. : 75-77-4 and Chloromethyl Isopropyl Carbonate (CMIC ) CAS No. 35180-01-9. Chemcon is the largest manufacturer in India since a decade for Hexamethyldisilazane. The processes for the manufacture of all these products have been developed and engineered in-house by the team of dedicated and expert in-house professionals with in-depth knowledge in the field. We enjoy the highest reputation among Indian as well as Multi-National Companies for being a leading HMDSO, CMIC, and Trimethyl Chlorosilane in India

Three of our most significant products are:

Hexamethyl Disiloxane (HMDSO) CAS NO. : 107-46-0

We specialize in the Manufacture of HMDSO in Gujarat which has many applications like:

•    HMDSO is a pharma intermediate which is very popular in the pharmaceutical industry due to its various applications.
•    It is an organosilicon compound, volatile in nature. It is also used as a reagent and a solvent in various organic syntheses.
•    It is also used as in spectroscopy to standardize the chemical shift.
•    The most important use of HMDSO is in crystallizing of lipophilic compunds.
•    Also used in preparation of liquid bandages.
•    It is manufactured through hydrolysis of trimethlsilyl chloride.

Trimethyl Chlorosilane (TMCS ) CAS NO. : 75-77-4

As India’s leading TMCS Manufacturer in Vadodara, we produce TMCS that has very useful applications in the field of pharmacy like:

•    Trimethyl Chlorosilane is used in the manufacture of all types of silicon compounds.
•    It is widely used in the manufacture of drugs and medicines.
•    It reacts with alcohol to produce anhydrous solutions of hydrogen chloride (HCL) in alcohols that can be used for the synthesis of esters.
•    It has also been used for silylation and as a protection group in the process of various organic syntheses.
•    But the most important application of TMCS is in the preparation of HMDSO.
•    Hydrolysis of TMCS in preparation of HMDSO:
TMCS is reactive toward nucleophiles, resulting in the replacement of the chloride. In a characteristic reaction of TMCS, the nucleophile is water, resulting in hydrolysis to give the Hexamethyl Disiloxane
2(CH3)3SiCl+H2O→ (CH3)3SiO(CH3)3Si+2HCl

Chloromethyl Isopropyl Carbonate (CMIC) CAS No. 35180-01-9

Chemcon prides in its manufacture of CMIC because of its outstanding application to prepare tenofovir. Tenofovir is regarded as a revolutionary drug for curing and preventing AIDS/HIV. Tenofovir disoproxil hemifumarate salt is basically prepared using dealkylating (R)-9-[2-(Diethyl phosphonomethoxy) propyl] adenine. To get a crystallized tenofovir in its stable form, Chloromethyl Isopropyl Carbonate is Used, where it is used to condense tenofovir during the latter’s initial phase of manufacture.

These are some of the importance of pharma intermediates which have revolutionalized the field of specialty chemicals worldwide and Chemcon is one of the world’s leading manufacturers of specialty chemicals and pharma intermediates.


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